Ligustrazine induces the colorectal cancer cells apoptosis via p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase

Background: Ligustrazine, active ingredients extracted from the natural herb Ligusticum Chuanxiong Hort, has promising anti-tumor properties on tumor cell lines. However, potential activity of ligustrazine colorectal cancer (CRC) cells and molecular mechanisms have not been elucidated. In this study, we explored critical functions SW480 CT26 at cellular levels.